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EC number: 227-873-2
CAS number: 6018-92-4
There are no mutagenicity studies available
for Trinickel dicitrate. However, extensive data exist on the
read-across substance nickel chloride.
Parts of the data are taken from the EU-RAR
for nickel chloride, dated 2008.
Nickel chloride has been extensively studied
De Flora et al. (1984) performed a
pre-incubation bacterial reverse mutation assay in S. typhimurium
strains TA 98, TA 100, TA 97, TA 1535, TA 1537 and TA 1538. This study
yielded a negative result like most of the studies performed. However,
two studies which were both fluctuation tests reported positive results.
One, in S. typhimurium, was reported only as an abstract (La Velle and
Witmer 1981). In the other, in Corynebacterium, no positive controls
were employed (Pikalet and Necasek 1983).
In mammalian cells, all in vitro mutation
and chromosomal aberrations test gave positive results (For details
refer to EU-RAR.).
A high number of animal studies indicate
that nickel chloride induces DNA damage and chromosome aberrations in
somatic cells in vivo. Data from in vivo micronucleus studies are
conflicting (see EU-RAR).
Dhir et al. (1991) studied the effects of
nickel chloride on chromosome aberrations (CA) and micronuclei (MN) in
Swiss albino mice after intraperitoneal administration of 10, 20 and 40
mg/kg bw. For the CA study, there were 3 exposure levels with a single
dose and three bone marrow samples were taken 6, 12 and 24 h after a
single dose. 50 metaphases/animal were scored. For the MN study, there
were again three exposure levels with 2 doses separated by 24 h. Bone
marrow samples were taken 24 and 48 h after the second dose and 500
cells/animal were counted. There was a significant and dose-related
increase in the chromosomal aberration rate. In the MN study, there was
also a significant and dose related increase in incidence of
micronuclei. There are no major differences in the NCE/PCE ratio at the
different dose levels.
La Velle JM, Witmer CM (1981). Mutagenicity
of NiCl2 and the analysis of mutagenicity of metal ions in a bacterial
fluctuation test. Environ Mutag 3: 320-321.
Pikalet P, Necasek J (1983): The mutagenic
activity of nickel in Corynebacterium sp. Folia Microbiol 28: 17-21.
Based on the available information from the
read-across substance nickel chloride Trinickel dicitrate needs to be
EU: Muta Category 3, R68
CLP: Category 2 germ cell mutagenicity
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