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EC number: 227-873-2
CAS number: 6018-92-4
Oral:LD50 cut-off = 500 mg/kg bw nickel hydrogencitrateDermal:LD50 > 2000 mg/kg bw nickel hydrogencitrate
The oral acute toxicity study has been
performed according to OECD guideline 423. First, groups of 6 female
Sprague Dawley rats received a single oral dose of 2000 mg/kg bw nickel
hydrogencitrate. All animals died within 72 hours after dosing.
Mortalities were preceded by a decrease in spontaneous activity
associated with partial ptosis, piloerection and bradypnea as well as a
decrease in muscle tone and righting reflex. Furthermore, increased
lachrymation was observed. In a second step, 6 female rats of the same
strain were dosed with 300 mg/kg bw nickel hydrogencitrate. No animal
died. At this dose level, there were no effects related to treatment.
The LD50 cut-off was determined as 500 mg/kg bw nickel hydrogencitrate.
No reliable acute study public available.
For the dermal route, a study according to
OECD guideline 402 has been performed with nickel hydrogencitrate in 5
Sprague Dawley rats of each sex at a single dose of 2000 mg/kg bw. No
mortality occured. There were no treatment-related effects. Therefore,
the LD50 was determined as higher than 2000 mg/kg bw.
Nickel hydrogencitrate and Trinickel
dicitrate are comparable: Since citric acid is a multifunctional acid,
at different pH values various intermediate ions like citrate,
hydrogencitrate and dihydrogencitrate are formed.
Based on the available data, the substance Trinickel
dicitrate needs to be cassified:
EU: R22 Harmful if swallowed.
CLP: Category 4
There is conclusive data available which is
not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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