Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1953
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature.
Data source
Reference
- Reference Type:
- publication
- Title:
- Maleic Anhydride and Maleic Acid
- Author:
- UNEP
- Year:
- 2 005
- Bibliographic source:
- Published OECD SIDS initial assessments of HPV chemicals (2005)
Materials and methods
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
- Details on test material:
- Name of test material :Maleic anhydride
Constituent 1
Test animals
- Species:
- other: Cat, rabbit, guinea pig, rat, mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 4.4 mg/liter
- No. of animals per sex per dose:
- One cat, one rabbit, one guinea pig, four rats, 10 mice
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
All animals had irritation of the eyes and respiratory airways. The guinea pig and 2/10 mice died due to bronchopneumonia.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
