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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1966
Reference Type:
publication
Title:
Experimental Studies on Skin Hazard with 'Versatic' 9-11 Acid and its Monoglycidyl and Vinyl Esters.
Author:
Hunter, C. G., Brown, V. K., Ferrigan, L. W.
Year:
1966
Bibliographic source:
Occupational and Environmental Medicine, 23(2), 137-141.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Brown et al. (1966)
Principles of method if other than guideline:
No further information available.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrahydrothiophene 1,1-dioxide
EC Number:
204-783-1
EC Name:
Tetrahydrothiophene 1,1-dioxide
Cas Number:
126-33-0
Molecular formula:
C4H8O2S
IUPAC Name:
1λ⁶-thiolane-1,1-dione
Constituent 2
Reference substance name:
Sulfolane
IUPAC Name:
Sulfolane
Details on test material:
- Name of test material (as cited in study report): Sulfolane

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Tunstall Laboratory Breeding Unit

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
1 ml
Duration of treatment / exposure:
6 hours, once per day for three applications
Observation period:
7 days after first application
Number of animals:
4 males and 4 females
Details on study design:
TEST SITE
Two 2 cm x 2 cm patches with 1 ml of test material were applied to the backs of rabbits and covered with a sheet of thin polythene. These were then bandaged into position by means of a 5 cm open-weave bandage.

REMOVAL OF TEST SUBSTANCE
- Not reported.

SCORING SYSTEM: According to Brown et al. (1966).

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: total for all 8 animals
Remarks:
Score according to Brown et al. (1966)
Time point:
other: final observations were made at 7 days
Score:
< 10
Max. score:
32
Remarks on result:
other: Non-irritating
Remarks:
Erythema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
Irritation parameter:
edema score
Basis:
other: total for all 8 animals
Remarks:
Score according to Brown et al. (1966)
Time point:
other: final observations were made at 7 days
Score:
0
Max. score:
32
Remarks on result:
other: not irritating
Remarks:
Edema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
Irritant / corrosive response data:
No information is available.
Other effects:
No information is available.

Any other information on results incl. tables

There was no sign of skin irritation in any of the rabbits. The use of sulphan blue showed the skin to be unchanged, and histopathological examination of skins taken from the rabbits post mortem revealed no evidence of skin damage.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Sulfolane is a non-irritant to rabbit skin.
Executive summary:

Sulfolane is a non-irritant to rabbit skin when applied under occlusive conditions for 6 hours a day on three consecutive days.