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Diss Factsheets
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EC number: 203-491-1 | CAS number: 107-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Principles of method if other than guideline:
- Method: other: RD50 determination
- GLP compliance:
- not specified
- Test type:
- other: determination of airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50)
Test material
- Reference substance name:
- 1,1,3,3-tetramethylbutylamine
- EC Number:
- 203-491-1
- EC Name:
- 1,1,3,3-tetramethylbutylamine
- Cas Number:
- 107-45-9
- Molecular formula:
- C8H19N
- IUPAC Name:
- 2,4,4-trimethylpentan-2-amine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: OF1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA Credo, Domaine des Oncins, Saint-Germain sur l´Abresle, France
- Weight at study initiation: 20-25 g
- Housing: groups of 10
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: housed for 7 days under controlled environmental conditions, brought to laboratory at least 1 day before each experiment
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Exposures were conducted in a 200 L stainless steel chamber, adjustable air flow 10-30 m3/h. Vapour was generated by passing air through liquid amines and diluting with further air before entry into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- RP-HPLC following derivatisation to m-toluol derivatives
- Duration of exposure:
- 60 - 120 min
- Concentrations:
- 6, 8, 17 and 24 ppm
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Upper airway irritation:
The breathing frequency was used as an index of upper respiratory tract irritation. Mice were restrained in a body plethysmograph while the head was enclosed in the inhalation chamber. Breath frequency measured with a pressure transducer before and during the 60 min exposure period. For each concentration the maximum decrease in respiratory rate occuring during the first 15 min was recorded. 4 concentrations were tested.
Pulmonary toxicity:
An intratracheal exposure was carried out in anaesthetised mice (pentobarbital, i.p.). Respiratory rate was measured in animals after recovery from anaesthesia for 75 min. Respiratory rate was monitored prior and during an 120 min exposure period. - Statistics:
- Differences in the respiratory rates: student´s t-test for paired data (level of significance P<0.05);
RD50, RD50TC and RD50TC/RD50: analysis as a function of the partition coefficients of the corresponding amines with least-squares linear regression
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: RD50
- Effect level:
- 80 ppm
- Exp. duration:
- 60 min
- Clinical signs:
- other: In uncannulated mice: rapid onset of response maximum around 1 min. After the 60 min exposure period recovery was only partial for t-octylamin treated mice (30 min recovery time). In cannulated mice bradypnoea developed slower (15-60 min).
Any other information on results incl. tables
The more lipophilic the amine, the higher was the sensory
irritation potential for upper and lower airways
(intratracheal exposure was conducted to study effects on
the lower airways).
With inhalation exposure the RD50 was 80 ppm, with
intratracheal exposure it amounted to 96 ppm.
Applicant's summary and conclusion
- Conclusions:
- In this pulmonary irritation study in the mouse a RD50 value of 80 ppm was found following exposure to vapours of the test item for 60 minutes.
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