Registration Dossier
Registration Dossier
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EC number: 203-921-8 | CAS number: 111-92-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of Toxicokinetic Behaviour
Absorption
Toxic effects have been observed after oral, dermal and inhalative exposure to the test substance. Therefore, an absorption via all three routes is likely. Furthermore, the test substance has a relatively low molecular weight of 129.2 g/mol which supports this assumption. Due to the moderate log Pow value (2.06), the test substance is favourable for absorption by passive diffusion by oral and inhalative route.
Distribution
Due to the relatively low molecular weight of 129.2 g/mol, the test substance is expected to have a relatively wide distribution.
Metabolism
The test substance includes an amino group (-NH2). This functional group in general tend to undergo Phase II conjugation reactions. In animals, the test substance is mainly metabolized to the corresponding carboxylic acid and urea. The intermediate compounds have been shown by in vitro experiments to be the corresponding aldehyde and ammonia.
Excretion
The relatively low molecular weight is an indicator for renal excretion. The substance is not expected to accumulate in the human body.
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