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EC number: 204-137-9
CAS number: 116-37-0
An eye irritation study according to OECD guidelines and GLP principles is available. A skin irritation study with exposure during 24h under occlusion on intact and abraded skin is available. Both showed that the substance is not irritating for skin and eye.
24 h reading is directly after
removal of the patches (with 24 h exposure), 72 h reading is 48 hours
after first reading.
A small lump of test substance was present
in the corner of the eye of all animals on Day 1. These remnants were
manually removed immediately after observing these.
In an in vivo skin irritation study, rabbits
were exposed to 0.5 g of 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2
–ol on intact or abraded skin for 24 h under occlusion.
Some slight irritation due to effects on erythema is observed directly
after exposure. This effect was decreased after 48 hours, mean score of
1. Therefore, it was concluded that the substance does not have to be
classified for skin irritation.
An in vivo eye irritation study is performed
according to OECD, EC, EPA and JMAFF test guidelines. Instillation of
approximately 48 mg of 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2
–ol (a volume of approximately 0.1 mL) into one eye of each
of three rabbits resulted in redness of the conjunctivae. The irritation
had completely resolved within 24 hours in two animals and within 48
hours in the other animal. No iridial irritation or corneal opacity was
observed, and treatment of the eyes with 2% fluorescein 24 hours after
test substance instillation revealed no corneal epithelial damage.
Therefore, the substance is considered to be not irritating to the
Based on the observed slight irritation of exposed abraded skin
after 24h of exposure, which effect was decreased after another 48h
(mean score is 1 at 72h
),1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2 –oldoes not have to
be classified and has no obligatory labelling requirement for dermal
irritation according to the:
- Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) of the United Nations (2007),
- Regulation (EC) No 1272/2008 on classification, labelling and
packaging of substances and mixtures.
Based on these results,
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2 –ol does not have to be
classified and has no obligatory labelling requirement for eye
irritation according to the:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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