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EC number: 204-137-9
CAS number: 116-37-0
An OECD 408 compliant 90 -day study in rat via oral route with
BPA-2PO resulted to aNOAEL of 180 mg/kg/day. The corrected 8 hr
inhalation NOAEC for workers is NOAEL (180) * 1.76 *1 *1.4 mg/m3 =
- 1 : factor 1 for route extrapolation from oral to inhalation is
applied However, it is worthy to note that due to very low vp (<0.0015
Pa), exposure is only possible as aerosol.
If any exposure via inhalation does occur, this can only be in the
form of larger droplets, as the use does not include fine spraying or
Droplets will deposit mainly on upper airways, and will be
subsequently swallowed following mucociliary transportation to pharynx.
This results to no principal differences in absorption compared to oral
route. Thus, apply a factor 1 is still a very conservatism approach.
- 1.4 : correction for differences between human and experimental
exposure condition (workers)
- 1.76 : correction for differences in respiratory volume
point: NOAEL of 180 mg/kg bw/day in a sub-chronic oral toxicity study in
rats. As oral absorption is considered to be 100 % and dermal absorption
is considered to be 10%, a factor of 10 for dermal absorption will be
applied. Thus, the modified dose descriptor starting point is 1800 mg/kg
Starting point: NOAEL of 180 mg/kg bw/day in a sub-chronic oral
toxicity study in rats.
Corrected inhalatory NOAEC = 180 * (1/1.15)* (1) = 156.52 mg/m3
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