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EC number: 272-338-9
CAS number: 68814-67-5
A complex combination obtained from various petroleum refining operations. It consists of hydrogen and hydrocarbons having carbon numbers predominantly in the range of C1 through C3.
Members of Other Petroleum Gases category are flammable gases at room temperature. Therefore, in accordance with section 2 of REACH Annex XI, neither skin nor eye irritation studies need be conducted. There are no indications that main constituents of the Petroleum Gases are skin or eye irritants, but direct skin or mucous membrane contact with liquid forms of C1- C4 alkane gases may cause burns and frostbite due to the extreme cold of the liquid. Mild rhinitis has only been reported following lifetime exposure to high concentrations of propene gas. Streams containing benzene will not trigger classification for irritation since this is present at less than 0.3% w/w in the category.
accordance with Section 2 of REACH Annex XI, studies on skin and eye
irritation do not need to be conducted as members of the Petroleum Gases
category are flammable gases at room temperature.
members are not expected to be irritating and this is confirmed by
pre-guideline rabbit skin and eye irritation studies on formulations
although these data cannot be relied upon since there are insufficient
details on how the test materials (as gases) were applied (Anon, 1982.
Final report of the safety assessment of isobutane, isopentane, n-butane
and propane, J American College of Toxicology, Volume 1, Number 4,
guideline studies available.
slight and transient erythema occurred randomly among the subjects
following repeated applications of aerosol products, containing a
mixture of isobutane and propane at 64.5% and 70% by weight,
respectively. The reactions were reported to be negligible. Both
isobutane and propane were considered practically non irritant to human
skin (Anon 1982).
skin contact with liquid forms of C1- C4 alkane gases may cause burns
and frostbite due to the extreme cold of the liquid (rapid evaporation
lowers the skin temperature causing frost injuries) (Cavender 1994).
propene has been used in humans at concentrations sufficient to induce
anaesthesia, there is only one literature report of potential adverse
irritation effects associated with repeated induction of anaesthesia in
one volunteer ¿after the first few breaths, there was usually slight
reddening of the eyelids with some lacrimation and flushing of the
eyes. Sometimes coughing would occur from pharyngeal irritation.¿ In
this study, to efficiently induce anaesthesia, very high concentrations
(688,000 ¿ 861,000 mg/m3) of propene were rapidly introduced (
and Riggs LK, 1931). This
information is not considered useful in assessment of the irritation
potential of propene gas, with its lower explosive limit of (34,000
mucous membrane contact with liquid forms of C1- C4 alkane gases may
cause burns and frostbite due to the extreme cold of the liquid
data exist for the C1-C4 alkanes. There are no indications of irritation
from repeat dose inhalation studies.
rhinitis (mild nasal inflammation) was reported in rats following
lifetime exposure to high concentrations of propene gas, a main
constituent in the category (NTP,1985) & (Harkema 2002). However, any
irritant properties in rodents were mild in nature, lacking a clear
dose-response relationship and reported only when high concentrations of
propene gas were maintained throughout lifetime exposure.
et al (1995) reported human exposure to propane at 100000 ppm (180 mg/L)
caused slight dizziness but no mucosal irritation of nose, eyes or
respiratory tract was observed.
is no evidence that members of this category are irritating to skin or
propene-induced rhinitis has been reported as mild in nature, occurring
in rodents only after lifetime exposure to high concentrations (5,000ppm
& 10,000ppm (8,600 and 17,200 mg/m3) of propene gas.
findings do not warrant classification for skin, eye, or respiratory
tract irritancy under DPD
(Dir 1999/45/EC) or GHS/CLP.
Streams containing benzene
will not trigger classification for irritation since this is present at
less than 0.3% w/w in the category (EU:R36/R38;
GHS/CLP: Cat 2 H319/Cat 2 H315 would
be triggered at levels of > 20 % or 10% respectively).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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