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EC number: 272-338-9
CAS number: 68814-67-5
A complex combination obtained from various petroleum refining operations. It consists of hydrogen and hydrocarbons having carbon numbers predominantly in the range of C1 through C3.
of exposure chamber atmospheres:Actual
concentrations were within a few per cent of target for each exposure..
There were no "untoward responses" to the acute exposures.
exposures to isobutane and isobutane/propane mixtures:
There were no untoward subjective responses or abnormal physiological
responses during or after these exposures. The following serial
laboratory studies were unaltered: complete blood count, urinalysis,
serum alkaline phosphatise, SGOT, LDH, serum bilirubin, blood sugar,
serum calcium, serum phosphorus, BUN, spontaneous electroencephalogram,
visual evoked response, a battery of cognitive tests and an ACTH
the final week of exposure a reduction in the amplitudes of the 3,4 and
5 waves was observed in the visual evoked response.
volunteers exposed to isobutane in a controlled environment chamber.
Acute exposure of 250-1000 ppm (594 -2377 mg/m3 (MW 58.12) ) for 1 min,
2 min, 1 hour, 2 hours and 8 hours. Repeat exposure at 500 ppm 1, 2 or 8
hours/day, five days/week for 2 weeks. Acute exposures to mixtures of
isobutane and propane for 1, 2 or 8 hours/day.
the investigations, all volunteers were kept under comprehensive medical
surveillance including cardiac and pulmonary responses (by continuous
ECG telemetry and serial computerised spirometric measurements).
exposures to isobutane at 250, 500 and 1000 ppm for periods of 1 min to
8 hours did not produce any "untoward physiological effect". Repeat
exposures to isobutane at 500 ppm for 1, 2 or 8 hours, 5 days/week for
ten exposures and mixtures of isobutane and propane were also without
any measurable "untoward physiological effect".
NOAEL > 1000 ppm (2377 mg/m3)
2 week exposure NOAEL >
500 ppm (1189 mg/m3)
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