Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity Data List VI
- Author:
- Smyth, H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: Modified Draize test
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylenediamine
- EC Number:
- 203-702-7
- EC Name:
- Trimethylenediamine
- Cas Number:
- 109-76-2
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,3-diamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur of the male albino New Zealand rabbits was removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film.
The animals were immobilized during the 24-hours contact period, after which the film is removed and the rabbits are caged for the subsequent 14-Day observation period. - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson* using the tables of Weil**.
*Thompson, W. R.: Use of Moving Averages and Interpolation to Estimate Median Effective Dose. Bacteriol. Rev. 11: 115 (June 1947).
**Weil, C. S.: Tables for Convenient Calculation of median-Effective Dose (LD50 or ED50) and Instruction in Their Use. Biometrics 8: 249 (Sep 1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 178 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 0.13 - <= 0.24
Any other information on results incl. tables
Details of toxic effects not reported other than lethal dose value.
Result in publication is given as 0.2 mL/kg (0.15 - 0.27 mL/kg ).
Density used by the registrant for conversion: 0.89 g/mL
Applicant's summary and conclusion
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