Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Méthode CEE, B1
GLP compliance:
yes
Test type:
standard acute method

Test animals

Species:
other: Rat Sprague Dawley

Administration / exposure

Vehicle:
other: Huile de maïs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 100 mg/kg bw
95% CL:
1 800 - 2 800
Mortality:
Male: 1300 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2400 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 4200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 1300 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2400 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 4200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
other: Signs of toxicity related to dose levels: A 4200 mg/kg une mort est survenue dans les 24 heures suivant l'administration du produit et les autres au 3ème jour. A 2400 mg/kg les morts sont survenues des jours 2 à 4. Les signes observés sont les suiva
Gross pathology:
Effects on organs:
L'observation macroscopique des organes a montré des
hémorragies de l'estomac, des poumons (1 animal) et du
thymus ainsi qu'une coloration du foie, des reins et tube
digestif.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU