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EC number: 608-544-6
CAS number: 3082-64-2
To two groups each of three fasted animals (males) a single oral dose of
the test material preparation in olive oil DAB 10 at dose levels of 500
and 2000 mg/kg body weight was given. Another group of six fasted
animals (3 males and 3 females) was treated in the same way with a dose
of 200 mg/kg body weight. Signs of toxicity noted in the 2000 and 500
mg/kg dose group comprised poor general state, dyspnoea, apathy, ataxia
and paresis. Twitching, saltatory spasm and flexion spasm were
additionally observed in rats of the 2000 mg/kg dose group. Symptoms
observed in the 200 mg/kg dose group comprised impaired or poor general state,
dyspnoea, apathy and staggering. The surviving animals appeared normal
within 5 hours after application. The expected body weight gain was
observed in the course of the study. All animals of the 500 and 2000
mg/kg dose group died within 1 hour after application. No mortality
occurred in the 200 mg/kg dose group.
Necropsy findings of the animals that died comprised severe hyperemia in
the glandular stomach and hyperemia of the mucosa in the small intestine (2000
mg/kg). No abnormalities were noted at necropsy of animals sacrificed at
the end of the study and of the animals of the 500 mg/kg dose group that
died. Under the conditions of this study the median lethal dose of (R)-1-Phenylpropylamin
after oral application was found to be greater than 200 mg/kg and less
or equal to 500 mg/kg body weight.
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