3-Furanol, tetrahydro-, (3S)-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP Study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-090-2

EC Name:

-

Cas Number:

86087-23-2

Molecular formula:

C4 H8 O2

IUPAC Name:

(3S)-oxolan-3-ol

Test animals

Species:

rat

Strain:

other: Alpk:APfSD (Wistar derived)

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: Liquid test substance applied undiluted.

Duration of exposure:

24 h

Doses:

2000mg/kg bodyweight

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: No deaths occurred and no signs of systemic toxicity were observed.

Gross pathology:

Effects on organs:
There were no treatment-related macroscopic findings at
examination post mortem.

Other findings:

Signs of toxicity (local):
Small scattered scabs were seen in one animal on days 7 to
10 and slight erythema was seen in one animal on day 2 only.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Following a study meeting the requirements of OECD guideline 402, the dermal LD50 of 1272W94 was estimated to be >2000mg/kg in male and female rats.

Executive summary:

A group of five male and five female ALPk:APfSD (Wistar derived) eats recieved a single occlusive dermal application of 2000mg/kg of 1272W94. The animals were assessed for the following 14 days for any signs of systemic toxicity and their bodyweights were recorded at intervals throughout the study. At the end of the study all animals were killed and subject to a macroscopic examination post mortem. No signs of toxicity were seen and none of the animals died before the end of the study. Slight signs of irritation were observed in 2 animals but had completely regressed by the end of the study. All animals gained weight satisfactorily and there were no findings seen post mortem. The acute dermal median lethal dose of 1272W94 was >2000mg/kg bodyweight in male and femal rats..