Registration Dossier
Registration Dossier
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EC number: 215-246-6 | CAS number: 1314-87-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Lead sulfide dust is injected in lungs via an intratracheal injection.
- GLP compliance:
- not specified
- Limit test:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- other: intratracheal
- Vehicle:
- physiological saline
- Doses:
- 50mg in 0.5mL of 0.15M saline solution
- No. of animals per sex per dose:
- 20
- Control animals:
- yes
Results and discussion
Any other information on results incl. tables
No remarkable lesions were observed in lungs from animals treated with galena (PbS).
Applicant's summary and conclusion
- Conclusions:
- In the conditions of the study, lead sulfide was not found toxic.
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