Registration Dossier
Registration Dossier
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EC number: 215-246-6 | CAS number: 1314-87-0
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: Case Report
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only Secondary litterature
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Type of study / information:
- Studies Report
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Summary of epidemiological studies that have investigated the relationship between soil/dust lead and blood lead concentrationsin urban towns and towns with operating smelters. Bioavailability of lead sulphide was evaluated thanks to these studies.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead sulphide
- EC Number:
- 215-246-6
- EC Name:
- Lead sulphide
- Cas Number:
- 1314-87-0
- Molecular formula:
- PbS
Constituent 1
Results and discussion
- Results:
- Lead in mine wastes, typically in the form of lead sulfide, is less bioavailable than lead typically found in street dusts, partly due to its lower solubility. One reason may be that lead Sulphide is less absorbed in the gastrointestinal tract compared to other lead species.
A second reason is that lead on smaller particles, particularly less than100µm in size, is absorbed more easily in the gastrointestinal tract. Sampling data have demonstrated that mine wastes can have particles greater than 100-150µm, and that most lead is lead sulphide.
Any other information on results incl. tables
Slopes values for inhalation exposure of lead sulphide were from 2 to 40 times lower than of others lead compounds.
Applicant's summary and conclusion
- Conclusions:
- Lead sulphide was found to have a low bioavailability.
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