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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 - 25 Jul 1991
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
lack of details on test substance
GLP compliance:
yes (incl. QA statement)
Remarks:
The department of health and social security of the government of the United Kingdom
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters
EC Number:
304-780-6
EC Name:
1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters
Cas Number:
94279-36-4
Molecular formula:
C36H60O6 to C42H72O6
IUPAC Name:
tris(C9-11-alkyl) benzene-1,2,4-tricarboxylate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River Ltd., Kent, UK
- Age at study initiation: 5-8 weeks
- Weight at study initiation: 152-165 g (males), 142-154 g (females)
- Fasting period before study: yes, overnight
- Housing: solid-floor polypropylene cages with sawdust bedding in groups of up to five by sex.
- Diet: Rat and Mouse Expanded Diet No. 1, Special Diet Services Ltd., Essex, UK., ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 24
- Humidity (%): 47 - 67
- Air changes (per hr): approx. 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 2.1 mL/kg
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and once daily thereafter.
- Frequency of weighing: on days 0, 7 and 14.
- Necropsy of survivors performed: yes (external examination and opening of the abdominal and thoracic cavities)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occured during the study period.
Clinical signs:
other: No clinical signs of toxicity were observed up to the end of the 14-day observation period.
Body weight:
other body weight observations
Remarks:
No effect on body weight was noted.
Gross pathology:
Necropsy and histopathological examination revealed no substance-related findings.

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Conclusions:
CLP: not classified