Registration Dossier
Registration Dossier
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EC number: 200-853-0 | CAS number: 75-24-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Toxicological testing is not applicable as the substance reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and also reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore it is not possible to calculate systemic DNELs for the substance. The toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium. Aluminium oxide and aluminium hydroxide are of low toxicity, are poorly absorbed by the oral, inhalation and dermal routes and are not classified for human health effects.
The test substance is classified as a Skin Corr. 1B. No dose response data are available therefore it is not possible to derive local DNEL values. Medium hazard is therefore assigned for local effects on the skin, eyes and respiratory tract in accordance with ECHA CSA Guidance part E Table E 3 -1.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
Toxicological testing is not applicable as the substance reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and also reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore it is not possible to calculate systemic DNELs for the substance. The toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium. Aluminium oxide and aluminium hydroxide are of low toxicity, are poorly absorbed by the oral, inhalation and dermal routes and are not classified for human health effects.
The test substance is classified as a Skin Corr. 1B. No dose response data are available therefore it is not possible to derive local DNEL values. Medium hazard is therefore assigned for local effects on the skin, eyes and respiratory tract in accordance with ECHA CSA Guidance part E Table E 3 -1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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