Registration Dossier
Registration Dossier
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EC number: 244-870-1 | CAS number: 22252-43-3
Endpoint summary
Administrative data
Description of key information
Subacute toxicity of 7-aminodesacetoxycephalosporanic acid was tested in three studies with Wistar rats, during 7 and 28 days.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 2 700 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
A decrease in ALAT was noted at 900 and 2700 mg/kg bw/day. As a decrease was seen and not an increase (which is considered an induction of liver activity), and since the decrease was not accompanied by other findings indicative of liver toxicity (e.g. liver weight, clinical biochemistry or histopathology), this finding is not considered toxicologically significant.
The NOEL is 300 mg/kg bw/day, the NOAEL is 2700 mg/kg bw/day.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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