Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in foreign language (Czech language) and documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Phenol metabolism in guinea pigs
Author:
Bardodej Z. and Krivucova M.
Year:
1961
Bibliographic source:
Cslka Hyg., 6(9), 553-554

Materials and methods

Objective of study:
metabolism
Test guideline
Guideline:
other: No data. If any guideline was followed, no details are given.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Veratrole
EC Number:
202-045-3
EC Name:
Veratrole
Cas Number:
91-16-7
Molecular formula:
C8H10O2
IUPAC Name:
1,2-dimethoxybenzene
Details on test material:
No data
Radiolabelling:
not specified

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not known

Administration / exposure

Route of administration:
other: not known
Vehicle:
not specified
Details on exposure:
Not known
Duration and frequency of treatment / exposure:
Not known
Doses / concentrations
Remarks:
Doses / Concentrations:
Not known
No. of animals per sex per dose / concentration:
Not known
Control animals:
not specified
Positive control reference chemical:
Not known
Details on study design:
Not known
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- No other information
Statistics:
Not known

Results and discussion

Preliminary studies:
Not applicable

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Not applicable
Details on distribution in tissues:
Not applicable
Details on excretion:
Not applicable

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Veratrole was demethylated to 2-methoxyphenol. From a Table presented in this Czech paper it is only possible to guess that the percentage of the administered dose that is metabolised to 2-methoxyphenol is between 6 and 22%.

Applicant's summary and conclusion

Conclusions:
Bioaccumulation potential cannot be judged based on study results