Registration Dossier
Registration Dossier
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EC number: 246-376-1 | CAS number: 24634-61-5
Carcinogenicity
Administrative data
Description of key information
Overall, dietary levels up to 10% of sorbic acid for 80 weeks in mice and 2 years in rats caused no carcinogenic effects.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 400 mg/kg bw/day
Justification for classification or non-classification
According to regulation (EC) No 1272/2008, potassium sorbate and sorbic acid are not carcinogenic.
Additional information
Potassium Sorbate at 0.1% in the diet or 0.3% in drinking water of rats for up to 100 weeks produced no neoplasms. In other chronic studies, no carcinogenic effect was demonstrated by Sorbic Acid in rats or mice fed diets containing up to 10% Sorbic Acid. Also rats fed at 10% of Sorbic acid for 3 years caused no carcinogenic effects.
The extrapolation effect from sorbic acid to potassium sorbate is considered not to be restricted in any way, since the determinant of potential toxicity is the sorbate anion.
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