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EC number: 232-029-1
CAS number: 7783-82-6
The mean body weights of the P and F1 generations from
all sodium fluoride treated groups were not
statistically different from their respective
controls. F1 generation male body weights were higher
than those of the P generation, but not significanly
There were no dose related effects on testis weight.
There were no significant differences in mean testis
weights between treated groups and controls in either
generation. The right testis weight and the paired
testis weights from the F1 generation controls were
significantly higher than the P generation controls.
The left testis weight of the F1 generation males was
significantly lower than that of the P generation
males in the 25 ppm group. The right testis weight of
the F1 generation males was significantly higher than
that of the P generation males in the 100 ppm group.
Statistically significant differences in mean
epididymal weights were not observed between control
and treatment groups of the P generation. Within the
F1 generation the right epididymal weight of the 175
ppm group was significantly lower than the F1 control.
No dose-related effects were observed. The weight of
the right epididymis from the F1 generation was
significantly lower than that of the P group when
epididymal weights for the 175 ppm group were
compared. Prostate/seminal vesicle weights were not
significantly different between treated and control
rats in either generation.
A statistically signifcant difference in body weight
was seen between the controls and the NaF-treated rats
in the 100 ppm, 175 ppm and a borderline statistically
significant effect was noted in the 250 ppm NaF
treatment groups. Decrease is not dose related. A
reduction in water consumption in higher dose groups
was observed. Indicating that dosing was at the limit.
There were no significant differences in spermatid
numbers between controls and treated rats in either
generation, or between generations. There were no
significant differences in serum testosterone, LH and
FSH concentrations between treated and control rats in
either generation or between generations. Liver weight
in the 250 ppm group (P generation) was significantly
lower than the control group. Spleen weights in the
175 and 250 ppm groups were significantly higher than
the control group. The authors considered these events
to be random and not treatment related because no
toxic effects were observed. Adrenal weights in the F1
generation were significantly lower than adrenal
weights in the P generation at all dose levels. No
dose-related toxic effects were observed and the
authors report that weight differences can arise from
the removal procedure. There were no treatment related
effects on the histopathology of the testis; the
histological appearance of the testicular tissue from
the control group was indistinguishable from that of
the high dose group in both generations. There were no
differences between the generations in the high dose
The potential of sodium fluoride (NaF) to affect
spermatogenesis and endocrine function was assessed in
P and F1 generation male rats. Male and female rats
received sodium fluoride in their drinking water at 0,
25, 100, 175 or 250 ppm. P generation rats were
exposed for 10 weeks, then for 3 weeks during mating.
Reproductive tissues were collected from P males 1
week after mating (after approximately 14 weeks of NaF
treatment). Pregnant females (P) were exposed to NaF
during gestation and lactation. F1 weanling males were
exposed to NaF for 14 weeks, at which time
reproductive tissues were collected. Dose-related
effects were not observed within the P and F1
treatment groups in testis weights, prostate/seminal
vesicle weights, non-reproductive organ weights,
testicular spermatid counts, sperm production per gram
of testis per day, sperm production per gram of
testis, LH, FSH or serum testosterone concentrations.
Histopathological changes in testicular tissues were
not observed. Prolonged exposure to NaF in drinking
water up to a dose of 250 ppm does not adversely
affect spermatogenesis or endocrine function in P and
F1 generation male rats
A quantitative examination of the testes of F1
generation males was made, following prolonged
exposure to sodium fluoride in the drinking water at
0, 25, 100, 175 or 250 ppm. The rats were exposed in
utero, during lactation, and directly in their
drinking water for 14 weeks after weaning. At the end
of the exposure period testicular tissues were
perfusion fixed and examined. There were no
statistically significant differences between controls
and treated rats in almost all the parameters
evaluated. A significant decrease in the absolute
volume and volume percent of the lymphatic endothelium
was observed in the 175 and 250 ppm groups, and in the
testicular capsule in the 100 ppm group. The authors
report that the significance of this finding is not
clear, and overall the results suggests that exposure
to NaF does not adversely affect testis structure or
spermatogenesis in the rat.
250 ppm of HF equals 42 ppm of WF6, which is
corresponding to 520 mg/m³ at 20°C and 1,013 bar.
Corrosion and acute effects are superceeding potential
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