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EC number: 232-029-1
CAS number: 7783-82-6
In a range-finding study, groups of five male and five female Fischer
344 rats were exposed to measured concentrations of 0, 1, 10, 25, 65 or
100 ppm (0, 0.83, 8.3, 21, 54 and 83 mg/m³) for 6 hours/day, 5
days/week, for 2 weeks; survivors were sacrificed 2 days later (Placke
et al, 1990). Exposures to 25 ppm (21 mg/m³) and above resulted in
deaths of all females, with deaths beginning on the eighth, third, and
second day of exposure at the 25, 65, and 100 ppm (21, 54 and 83 mg/m³)
concentrations, respectively. Exposures to 65 and 100 ppm (54 and 83
mg/m³) resulted in deaths of all males, with deaths beginning on the
third and second day at the 65 and 100 ppm concentrations, respectively.
No deaths occurred during the first day of exposure at any
concentration, and no deaths occurred at the lower concentrations.
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