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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-ethyl-4-methylimidazol
- Physical state: solid

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
100, 147, 215, 316 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 200 mg/kg bw
Based on:
test mat.
Mortality:
0/10 animals died at 100 mg/kg bw
0/10 animals died at 147 mg/kg bw
6/10 animals died at 215 mg/kg bw
10/10 animals died at 316 mg/kg bw
deaths occured within 1 hour
Clinical signs:
Dyspnea, apathy, belly-side position, staggering, atony, tremors, twitching, spastic gait, tonic-clonic convulsions, exophthalmos, poor general condition
Gross pathology:
No precipitation or adhesions.

Applicant's summary and conclusion