Registration Dossier
Registration Dossier
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EC number: 213-234-5 | CAS number: 931-36-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- BASF-Test. Rabbits were dermally exposed to a 50% aqueous solution of 2-ethyl-4-methylimidazol (400mg/kg) for 24 hour. Mortality and clinical symptoms were recorded over 8 days. Section was performed after the 8 day follow up.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethyl-4-methylimidazole
- EC Number:
- 213-234-5
- EC Name:
- 2-ethyl-4-methylimidazole
- Cas Number:
- 931-36-2
- Molecular formula:
- C6H10N2
- IUPAC Name:
- 2-ethyl-4-methyl-1H-imidazole
- Details on test material:
- - Name of test material (as cited in study report): 2-Äthyl-4(5)-methylimidazol; EMI 2,4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.GAUKLER (6050 Offenbach, Germany)
- Weight at study initiation: 2.77 kg (males) and 2.81kg (females)
- Diet: Ssniff K, standard diet for rabbits and guinea pigs (Firma INTERMAST GMBH, Soest), ad libitum
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Dorsal and lateral sides of the animals were shaved with an electric clipper approximately 15-24 hour prior to exposure.
- Only animals with a healthy appearance and unijured skin were used for the experiments
- Coverage: approximately 180 cm2
- Type of wrap if used: aluminium foil fixed with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water or a water/Lutrol mixture
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration: 50% solution
- Dose: 400 mg/kg bw - Duration of exposure:
- 24 hour
- Doses:
- 400 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: after 1, 24 and 48 hours and on day 8
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the observation period.
- Clinical signs:
- other: No abnormal observations were reported.
- Gross pathology:
- No treatment related findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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