Praseodymium trinitrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Sufficiently documented acute oral toxicity study in female rats performed according to a method equivalent to OECD Guideline 401.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1963

Reference 2

Reference Type:

secondary source

Title:

Sax's Dangerous Properties of Industrial Materials

Author:

Lewis

Year:

1995

Bibliographic source:

9th ed, Van Nostrand Reinhold, New York page 2389

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Praseodymium trinitrate

EC Number:

233-796-5

EC Name:

Praseodymium trinitrate

Cas Number:

10361-80-5

Molecular formula:

HNO3.1/3Pr

IUPAC Name:

praseodymium trinitrate

Details on test material:

- Name of test material (as cited in study report): Praseodymium nitrate
- Analytical purity: > 98%
- Other: Praseodymium nitrate was obtained from the Lindsay Chemical Company, West Chicago, Illinois, and the K and K Laboratories, Jamaica, New York. The six hydrate form was tested (6H2O).

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: adult
- Weight at study initiation: 190 g to 250 g
- Fasting period before study: no data
- Housing: Animals were housed in air-conditioned quarters
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
50% aqueous solution

Doses:

unknown

No. of animals per sex per dose:

5 or 10 animals per group

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 30 days

Statistics:

On the basis of the mortality that occurred during the 30-day observation period, the LD50 values with 95% confidence limits were calculated by the method of Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

3 500 mg/kg bw

Based on:

test mat.

95% CL:

3 017 - 4 060

Mortality:

The animals were observed for 30 days although no deaths occurred later than 4 days after administration of the nitrate salts by the oral route.

Clinical signs:

other: Within 1 to 2 hours after oral administration of the rare earth nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period.

Gross pathology:

Throughout the observation period no gross pathologic changes were noted.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 of praseodymium nitrate in female rats was determined to be 3500 mg/kg. The test substance is considered not classified according to the criteria of the CLP Regulation.