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EC number: 618-126-5
CAS number: 88196-70-7
The evaluation depends on the solubility of the test substance, the
tested concentrations and the time until appearance of unambiguous
intravascular coagulation of middle-sized vessels or extravascular
coagulation of the treated CAM, respectively. The mean time until
appearance of reaction over the eggs of a treatment group was calculated
(mean time to coagulation = mtc in seconds):
mtc(100%) < 90 "risk of serious damage to the eyes"
mtc(100%) x 0.019 + mtc(10%) x 0.017 < 4.404 "risk of serious damage to
mtc(100%) ≥ 90 "no risk of serious damage to the eyes"
0 No visible change
1 Slight reaction
2 Moderate reaction
3 Severe reaction
The potential of rac-1-(3-Methoxyphenyl)ethylamine to cause serious
damage to the eyes/mucous membranes was assessed by a single topical
application of 0.3 mL of the undiluted test substance and 0.3 mL of a
10% test-substance solution in olive oil Ph.Eur./DAB, to the
chorionallantoic membrane (CAM) of fertilized and incubated hen eggs. Three
eggs per test-substance concentration were observed until unambiguous
irritation reactions were detected or up to a maximum time period of 210
seconds. The occurrence of vascular injury or intravascular coagulation
in response to the test substance was recorded. The undiluted test
substance caused severe intravascular as well as extravascular coagulation
and moderate haemorrhagia in all eggs within 9 – 12 seconds after
application. The 10% test substance solution in olive oil Ph.Eur./DAB
caused moderate intravascular coagulation in all eggs after 49 – 85
seconds and moderate haemorrhagia in all eggs within 11 – 17 seconds. Based
on the results of this study it was concluded, that
rac-1-(3-Methoxyphenyl)ethylamine causes serious eye damage in the HET-CAM
Test under the test conditions.
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