Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 604-314-4 | CAS number: 142844-00-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The biopersistence of RCF/ASW fibres
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Full ADME studies have not been carried out on any fibre. Access to the body is determined by respirability a function primarily of fibre diameter and secondarily of length. Only fibres released during handling and use become airborne and available for inhalation. No studies have demonstrated that fibres as large as these vitreous man made fibres leave the lung and gut and become located elsewhere in the body. Excretion occurs after fibres are attacked by the aqueous environment or by macrophages, processes not normally regarded as metabolism, the damaged fibres fragment and are removed to and then from the gut in faeces.
Because of this the substance under consideration has a low ability to persist and accumulate in the body.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
