Registration Dossier
Registration Dossier
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EC number: 404-110-3 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The determination of the rate of hydrolysis was not possible.
Key value for chemical safety assessment
Additional information
In the supportive study the potential for hydrolysis of the test item at different pH-values was assessed according to the DIRECTIVE 84/449/EEC (corresponding to COMMISSION REGULATION (EC) No. 440/2008, method C.7, equivalent to OECD 111). The study was performed compliant with GLP.
As the test item is insoluble in water (<1 µg/L, see IUCLID section 4), requirements on water solubility as given by the test guideline could not be met. In order to increase the water solubility of the test item the organic solvent DMF was applied. According to the guideline, the use of solvents should not exceed 1% of the buffer solution. At this concentration (buffer:DMF 99:1 (v:v)) no increase of water solubility was observed, independently of the pH.
As a result, the determination of the rate of hydrolysis was not possible because the test item was not soluble in water. Precipitation occurred in all prepared test item solutions at pH 4, 7, and 9 within one day. After 5 days all test item solution were completely clear and the UV-VIS spectroscopic analysis did not show any absorption in the visible light spectrum.
In conclusion, no determination of the rate of hydrolysis for the test item was possible.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
