Registration Dossier
Registration Dossier
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EC number: 261-235-4 | CAS number: 58398-71-3
Endpoint summary
Administrative data
Description of key information
Calcium magnesium dihydroxide oxide is considered to be irritating to skin and the respiratory system and entails a risk of serious damage to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The results of an available in vivo skin irritation studies (rabbit) indicate that calcium magnesium dihydroxide oxide may be irritating to skin (pH effect) by read-across.
In the available eye irritation studies (in vivo, rabbit), both CaO and Ca(OH)2 caused irreversible lesions in the eye. By read across the results are also applicable for calcium magnesium dihydroxide oxide.
From human data on calcium oxide and hydroxide it is concluded by read-across (worst case approach) that calcium magnesium dihydroxide oxide is irritating to the respiratory tract.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on experimental results on a similar substance utilised by read-across, calcium magnesium dihydroxide oxide requires classification as irritating to skin [R38, irritating to skin; Skin Irrit 2 (H315 – Causes skin irritation)].
Based on experimental results on a similar substance utilised by read-across, calcium magnesium dihydroxide oxide requires classification as severely irritating to the eye [R41, Risk of serious damage to eye; Eye Damage 1 (H318 - Causes serious eye damage)].
Based on human data as summarised and evaluated in the SCOEL recommendation (Anonymous, 2008: Recommendation from the Scientific Committee on Occupational Exposure Limits for Calcium oxide (CaO) and calcium hydroxide (Ca(OH)2), European Commission, DG Employment, Social Affairs and Equal Opportunities, SCOEL/SUM/137 February 2008, see section 7.2.2 of the technical dossier), it is proposed to classify calcium magnesium dihydroxide oxide as irritating to the respiratory system [R37, Irritating to respiratory system; STOT SE 3 (H335 - May cause respiratory irritation)].
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