Registration Dossier
Registration Dossier
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EC number: 245-322-4 | CAS number: 22914-58-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Only standard information required at REACH Annex VIII is available for assessing the toxicokinetics for the test substance. The available test data do not permit extensive conclusions concerning absorption, metabolism or excretion to be conclusively drawn. Acute toxicity via the inhalation route was observed alongside effects in the available OECD 422 study (repeated dose/repro screening study).
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The substance is a metal complex and accordingly bioaccumulation is less relevant.
Repeated oral administration of the test substance (in an OECD 422 study) to rats provided a parental NOAEL 60 mg/kg/day for general systemic toxicity and 125 mg/kg/day for reproductive /developmental toxicity (highest dose). The parental effects included tubular degeneration/regeneration in the kidneys in males indicating the kidney as a target organ. In the dose range finder, mortality was observed at doses of 250, 500 and 1000 mg/kg/day indicating that these doses would not be tolerated.
In a previously conducted acute oral inhalation study mortality and adverse clinical signs were observed providing an LC50 value of > 1.06 and < 4.8 mg/L.
No treatment related changes were observed in any of the developmental or reproductive parameters in the OECD 422 study, possibly indicating low adsorption through the placenta to directly affect the foetuses and similarly as no effects were observed in pups during the lactation phase, low exposure to the developing pups via lactation is likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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