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REACH

sec-butyl chloroformate

EC number: 241-475-6 | CAS number: 17462-58-7

Life Cycle description
Uses advised against

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

Hydrolysis product sec-butanol: With high probability not acutely harmful to aquatic algae.
Hydrolysis product HCl: Acutely very toxic to aquatic algae (pH dependent).

Key value for chemical safety assessment

Additional information

There are no data available concerning the parent compound. With the hydrolysis product sec-butanol a weight-of evidence approach indicates that most likely there will be no harmful effects since the EC50 is not expected to be < 100 mg/L. Experimental results from 7-8 -d growth inhibition tests with the green algaScenedesmus quadriquada and with the blue-green alga Microcystis aeruginosarevealed EC3 values of 95 mg/L and 312 mg/L, respectively (OECD, 2002). With ECOSAR, a 96 -h EC50 of 451 mg/L was calculated (BASF SE; 2008).

The hydrolysis product HCl showed acutely very toxic effects due to the low pH: 72 -h EC50 = 0.492 mg/L (OECD, 2002).

Species	Results	Remarks	Reference
Scenedesmus quadricauda	EC₃(7 d) = 95 mg/L (nominal); algae growth inhibition test	Hydrolysis product sec-butanol; reliability: 2; supp. study	OECD, 2002
Microcystis aeruginosa	EC₃(8 d) = 312 mg/L (nominal); algae growth inhibition test	Hydrolysis product sec-butanol; reliability: 2, supp. study	OECD, 2002
Green algae	EC₅₀= 451 mg/L (ECOSAR estimation)	Hydrolysis product sec-butanol; reliability: 2; supp. study	BASF SE, 2008
Pseudokirchneriella subcapitata (formerly:Selenastrum capricornutum)	EC₅₀(72 h) = 0.492 mg/L (acid equivalent to pH 5.3), NOEC (72 h) = 0.097 mg/L (acid equivalent to pH 6.0), with analytical monitoring, OECD TG 201	Hydrolysis product HCl; reliability: 2; key study	OECD, 2002

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