Registration Dossier
Registration Dossier
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EC number: 231-744-6 | CAS number: 7718-98-1
Endpoint summary
Administrative data
Description of key information
VCl3 is very hygroscopic and gives, in contact of humidity :
VCl3 + H2O => VOCl + 2 HCL
VOCl + 1/2Cl2 => VOCl2
The dissolution reaction in water is instantaneous (half-life of VCl3 < 1 hour – VCl3 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.
Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl3 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
With the physico-chemical properties (HCl generation) and the weight of evidence (industrial practice), VCl3 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations. For this reason, no classification for acute toxicity could be set.
Some oral LD50 are collected but due the date of data (1965 and 1969) and the absence of details, these LD50 are not selected for classification (it is possible the cause of death is the effect of the corrosive property on the digestive tractus).
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