Registration Dossier
Registration Dossier
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EC number: 218-212-9 | CAS number: 2082-59-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (1989)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.33
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 95 % confidence limits: (3.14 - 3.52)
- Details on results:
- The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
- Conclusions:
- The partition coefficient of the substance was determined at log Pow = 3.33 at 25°C and pH7.
- Executive summary:
The partition coefficient of the substance was determined according to EU Testing Guideline A.8 "Determination of the partition cofficient, HPLC method", based on OECD guideline 117. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values. The test item showed a result of log Pow = 3.33 (95 % confidence limits 3.14 - 3.52), which indicates considerable lipophilicity.
Reference
The log Pow value of the test compound was calculated from its log k' and the calibration line to be (at 25 °C):
| Compound | retention time [min] | log k' | log Pow | |||
| 1. | 2. | 3. | mean | |||
| Test item | 3.68 | 3.69 | 3.69 | 3.69 | 0.40 | 3.33 |
Description of key information
The partition coefficient of the substance was determined at log Pow = 3.33 at 25°C and pH7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.33
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
