Registration Dossier
Registration Dossier
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EC number: 206-586-6 | CAS number: 355-43-1
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.02.2007 to 27.04.2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-6-iodohexane
- EC Number:
- 206-586-6
- EC Name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-6-iodohexane
- Cas Number:
- 355-43-1
- Molecular formula:
- C6F13I
- IUPAC Name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-6-iodohexane
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- pH:
- The pH of the activated sludge inoculum was adjusted from 8.8 to 7.2 with a diluted sulfuric acid solution.
- Nominal and measured concentrations:
- 1000 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrations
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Results with reference substance (positive control):
- The 3-hour EC50 of the reference item 3,5-dichlorophenol (positive control) was calculated to be 17 mg/L with 95% confidence limits from 1 to 241 mg/L. The 3-hour EC50 is within the guideline-recommended range of 5-30 mg/L, confirming the suitability of the activated sludge used.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- NOEC(3h) > 1000 mg/L
- Executive summary:
The test item had no significant inhibitory effect (<15%) on the respiration rate of activated sludge after the incubation period of three hours at the limit test concentration of 1000 mg/L.
Thus, the 3-hour NOEC (EC 15) of the substance to activated sludge microorganisms was at least 1000 mg/L. This value might even be higher, but concentrations above 1000 mg/L were not tested. The 3-hour EC20, EC50, and EC80 could not be calculated, but were clearly higher than 1000 mg/L.
The oxygen consumption rates of the two controls (run at the start and at the end of the test) differed by 8% (guideline-recommended maximum variation: 15%).
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