Registration Dossier
Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d, nitrate formation rate): ≥ 31.71 mg a.i./kg soil dw (nominal, OECD 216, soil)
NOEC (28 d, short-term respiration): ≥ 31.71 mg a.i./kg soil dw (nominal, OECD 217, soil)
Key value for chemical safety assessment
Additional information
Two key studies and one supporting study on the toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to soil microorganisms are available.
The available key studies (2010) on the toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to soil microorganisms were performed according to the OECD Guidelines No. 216 (nitrogen transformation rate, GLP) and 217 (carbon transformation rate, GLP). For these studies agricultural soil was treated with 0 (control and solvent control), 12.69 and 31.71 mg a.i./kg soil dry weight (dw) and incubated for 28 d (carbon transformation) and 70 d (nitrogen transformation). During the incubation period, short-term respiration and nitrate formation of soil subsamples were measured at 0, 7, 14, 28 d after application. Furthermore, nitrate formation of the soil microorganisms was additionally measured at 42, 56, 70 d after application. The test item had no impact on nitrogen transformation (28 days after applications) or soil respiration (28 days after applications) of soil microorganisms when applied at 12.69 mg and 31.7 mg test item/kg soil dry weight treatment.
The key results are supported by the results of a further study (2000), which was performed with the product Thiram 80 WG. This study was conducted according to the BBA-Guideline for the Official Testing of Pesticides, Part VI, 1-1 (1990), under GLP conditions. Thiram 80 WG was applied to two different soil types and incubated for 90 days (soil 1, nitrogen turnover) and 28 days (soil 2, short-term respiration), and the effects on soil microflora activity was recorded. At test termination, no significant effects on short-term respiration and nitrogen turnover were detected, not even at the highest concentration tested, resulting in a 28 d and 90 d NOEC of ≥ 32.48 mg a.i./kg soil dw (nominal), respectively.
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