p-mentha-1,4-diene

Endpoint summary

Description of key information

Absorption

oral/GI absorption

The Molecular Weight of p-mentha-1,4-diene is 136.24 less than 500 which are favourable for absorption.

The substance is Water-soluble and has a low molecular weight less than 500.

It’s more easily to be taken up and will readily dissolve into the gastrointestinal fluids.

It also may pass through aqueous pores or be carried through the epithelial barrier by the bulk passage of water.

The LogPOW is >4 which indicates that the substance may be taken up by micellular solubilisation.

The test item Gamma Terpinene administered to 6 females at dose of 2000 mg/kg body weight did not cause death. No signs of toxicity were observed during the first 4 hours in females and within the 14-day observation period thereafter. No body weight losses were observed between one and two weeks after administration of the test item. During necropsy, no macroscopic findings were observed.

AfterRepeated dosetoxicity,28d study(oral), The test item

- did not cause mortality of animals

- had no visible toxic effect on animals

- had no influence on haematological and clinical chemistry parameters

- did not cause changes in urine

- did not cause of macroscopic findings on the examined organs

- had no influence on the locomotor activity, reaction time and grip strength

- did not cause histopathological changes on examined organs

Therefore the substance’s not easy to be absorbed by oral route.

 

Respiratory absorption – Inhalation

The substance’s boiling point is more than 150 oC and has low volatility. it is not easily absorbed by Inhalation.

The LogPOW is >4 and the substance may be taken up by micellular solubilisation

 

Dermal absorption

The substance is liquid and is more readily dermal uptake.

The water solubility is 7.44 mg/l and indicates that absorption is anticipated to be low to moderate. Log P is above 4, the rate of penetration may be limited by the rate of transfer between the stratum corneum and the epidermis, but uptake into the stratum corneum will be high.

 

The rate at which gases and vapours partition from the air into the stratum corneum will be offset by the rate at which evaporation occurs therefore although a substance may readily partition into the stratum corneum, it may be too volatile to penetrate further. This can be the case for p-mentha-1,4-diene with vapour pressures above 100-10,000 Pa (ca. 0.76-76 mm Hg) at 25°C, though the extent of uptake would also depend on the degree of occlusion, ambient air currents and the rate at which it is able to transfer across the skin.

 

The test item Gamma Terpinene applied to 5♀ and 5♂ at a limit dose of 2000 mg/kg body weight did not cause death. All females and males survived the limit dose of 2000 mg/kg body weight. No body weight losses in males and mildly increase and decrease or stagnation in females were observed between one and two weeks after application of the test item. No signs of toxicity were observed at the dosage of 2000 mg/kg body weight during the first 4 hours in females or 14-day observation period. No dermal changes were observed. During necropsy no macroscopic findings were noticed. There is no evidence that the substance can be absorbed by the animal by dermal route.

 

Distribution

The LogPOW is >0. It is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.