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Diss Factsheets
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EC number: 201-279-3 | CAS number: 80-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Dicumyl peroxide is not genotoxic/mutagenic.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
Dicumyl peroxided was tested negative in the complete suite of in-vitro genotoxicity studies hence in vivo studies are not required.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Genetic toxicity in vitro
Bacterial test systems detecting gene mutations
An Ames test was performed by MHW Japan (2000). In this guideline study according to OECD 471 using Salmonella typhimurium strains TA100, TA1535, TA98, TA1537 or Escherichia coli WP2 uvrA strains at concentrations 0, 0, 313, 625, 1250, 2500 and 5000 µg/plate DCP was found to be negative, both with and without metabolic activation system (S9 mix).
This result is in line with several other Ames tests, all indicating that DCP did not induce gene mutations in bacteria.
Chromosome mutations in mammalian cells
A chromosome aberration study in Chinese hamster lung (CHL) cells was carried out by MHW Japan (2000). This assay was conducted both with and without metabolic activation system (S9 mix) at 6 dose levels from 20 to 225 µg/mL. Toxicity was observed at the high dose tested in each treatment condition (with and without S9 mix).
Under the conditions of the assay, DCP did not induce structural or numerical chromosome aberrations in CHL cells when tested both in the presence as well as in the absence of an exogenous metabolic activation system. DCP was concluded to be negative in the CHO chromosome aberrations assay.
Gene mutations in mammalian cells
Effects of dicumyl peroxide on gene mutation in mammalian cells were investigated in a study according to OECD guideline 476. Chinese hamster lung fibroblasts were exposed with and without metabolic activation system (S9 mix). No increase in gene mutation at the HPRT locus was observed when tested up to 156.3 µg/mL with and up to 39.1 µg/mL without S9 mix.
Genetic toxicity in vivo
Further testing on genotoxicity in vivo is not considered necessary based on the negative outcome of the tests performed in vitro.
Justification for classification or non-classification
Based on the results of reliable studies classification for genotoxicity is not warranted according to EU regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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