Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-856-5
CAS no.:
111-30-8
Index number:
Molecular formula:
C5H8O2
SMILES:
O=CCCCC=O
InChI:
InChI=1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
9
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP09) approved by the European Union, this substance is fatal if inhaled, is toxic if swallowed, causes severe skin burns and eye damage, is very toxic to aquatic life, is toxic to aquatic life with long lasting effects, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes serious eye damage.

Breakdown of all 1990 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Acute Tox. 3 H301 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317
Acute Tox. 3 H331
Acute Tox. 2 H330 Harmonised Classification
Eye Dam. 1 H318
STOT SE 3 H335 Harmonised Classification
Aquatic Chronic 2 H411 Harmonised Classification
Skin Sens. 1A H317 Harmonised Classification
Met. Corr. 1 H290
Skin Corr. 1C H314
Acute Tox. 5 H313
Skin Sens. 1B H317
https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 10 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 4 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: disinfection, veterinary hygiene, food and animals feeds, product preservation, preservation for liquid systems, controlling slimes.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: biocides (e.g. disinfectants, pest control products) and leather treatment products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and health services. This substance is used for the manufacture of: textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, laboratory work, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: leather treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes, laboratory work, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

This substance is used in the following products: leather treatment products.

This substance is used in the following areas: scientific research and development and agriculture, forestry and fishing. This substance is used for the manufacture of: textile, leather or fur, chemicals, rubber products and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, laboratory work and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: as processing aid, in the production of articles, as processing aid and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • B-Lands Consulting (811697-8), OR of HUBEI JINGHONG CHEMICAL CO., LTD 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • B-Lands Consulting (811704-7), OR of Hubei Microbial Control Biological Technology Co.,LTD 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • REACH24H CONSULTING GROUP(acting as OR for Jingzhou Xinjing Chemical Co., Ltd), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • Schill + Seilacher GmbH, Schoenaicher Str. 205 71032 Boeblingen Germany
  • Specialty Electronic Materials Belgium, BV, Rue Jules Bordet 7180 Seneffe Belgium
  • Specialty Electronic Materials Netherlands BV, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • Thomasker Finechemicals Ltd., Cziráki u. 26-32. 1163 Budapest Hungary

Substance names and other identifiers

1,3-Diformylpropane
Other
Aldehyd glutarowy
Other
Aldesan
Other
Aldesen
Other
Alhydex
Other
Cidex
Other
glutaral; glutaraldehyde; 1,5-pentanedial
EU. Worker Protection-Hazardous (98/24), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Glutaraldehyde
C&L Inventory, Other, EU. Cosmetics Regulation Annex V, Allowed Preservatives, EU. Dangerous Substances - Eco-Labels
Glutaralum
Other
Glutardialdehyde
Other
Glutaric acid dialdehyde
Other
Glutaric aldehyde
Other
Glutaric dialdehyde
Other
Glutarol
Other
Hospex
Other
Pentane-1,5-dial
EU. Cosmetics Regulation Annex V, Allowed Preservatives
Sonacide
Other
1,5-pentaandiaal (et)
C&L Inventory
1,5-pentandial (hr)
C&L Inventory
1,5-pentandiale (it)
C&L Inventory
1,5-pentandialis (lt)
C&L Inventory
1,5-pentanedial (fr)
C&L Inventory
1,5-pentanodial (es)
C&L Inventory
1,5-pentándial (hu)
C&L Inventory
1,5-pentāndiāls (lv)
C&L Inventory
1,5-пентандиал (bg)
C&L Inventory
gluraraldeide (it)
C&L Inventory
Glutaaral (glutaaraldehyde) (nl)
Biocidal active substances
glutaaraldehyd (nl)
C&L Inventory
glutaaraldehüüd (et)
C&L Inventory
Glutaraal (et)
C&L Inventory
Glutaraal (glutaaraldehüüd) (et)
Biocidal active substances
Glutaraali (glutaarialdehydi) (fi)
Biocidal active substances
glutaral (cs)
C&L Inventory, Biocidal active substances
Glutaral (aldehyd glutarowy) (pl)
Biocidal active substances
Glutaral (glutaraldehid) (hr)
Biocidal active substances
Glutaral (Glutaraldehidă) (ro)
Biocidal active substances
glutaral (glutaraldehyd) (cs)
Biocidal active substances
Glutaral (Glutaraldehyde) (mt)
Biocidal active substances
Glutaral (glutaraldehído) (es)
Biocidal active substances
Glutaral (glutaraldeído) (pt)
Biocidal active substances
Glutaral (glutaraldéhyde) (fr)
Biocidal active substances
glutaraldehid (hr)
C&L Inventory
glutaraldehida (ro)
C&L Inventory
glutaraldehyd (cs)
C&L Inventory
glutaraldehydi (fi)
C&L Inventory
glutaraldehído (es)
C&L Inventory
glutaraldeído (pt)
C&L Inventory
glutaraldéhyde (fr)
C&L Inventory
glutarale (it)
C&L Inventory
Glutarale (Glutaraldeide) (it)
Biocidal active substances
glutaralis (lt)
C&L Inventory
Glutaralis (glutaraldehidas) (lt)
Biocidal active substances
Glutardialdehyd (de)
C&L Inventory
glutaro aldehidas (lt)
C&L Inventory
glutarál (sk)
C&L Inventory
Glutarál (Glutáraldehid) (hu)
Biocidal active substances
glutarāls (lv)
C&L Inventory
Glutarāls (glutāraldehīds) (lv)
Biocidal active substances
glutáraldehid (hu)
C&L Inventory
glutáraldehyd (sk)
C&L Inventory
glutāraldehīds (lv)
C&L Inventory
pentaanidiaali (fi)
C&L Inventory
pentandial (cs)
C&L Inventory
pentano-1,5-dial (pl)
C&L Inventory
pentándiál (sk)
C&L Inventory
pentándiál (glutáraldehyd) (sk)
Biocidal active substances
Γλουταράλη (γλουταραλδεΰδη) (el)
Biocidal active substances
γλουταραλδεΰδη (el)
C&L Inventory
глутарал (bg)
C&L Inventory
Глутарал (глутаралдехид) (bg)
Biocidal active substances
глутаралалдехид (bg)
C&L Inventory
Pentanedial
Other
1,5-Pentandiol
C&L Inventory
Glutar aldehyde
C&L Inventory
glutaral, glutaraldehyde, 1,5-pentanedial
C&L Inventory
Glutaraldehyde - Solution (50 %)
C&L Inventory
pentane 1,5 dial
C&L Inventory
1,5-pentanedial (IUPAC and CTPA name)
Registration dossier
1,5-Pentanedione
Registration dossier
1,5-pentanedione (alternative chemical name)
Registration dossier
AQUCAR™ GA 50 MUP Antimicrobial
Registration dossier
AQUCAR™ GA 50 Water Treatment Microbiocide
Registration dossier
Basolon GDA 50
Registration dossier
BIOBAN™ GA 50 Antimicrobial
Registration dossier
Common name: Glutaraldehyde
Registration dossier
Glutaclean
Registration dossier
Glutaral (INCI name)
Registration dossier
Glutaraldehyde (6CI, 8CI)
Registration dossier
Glutaraldehyde (common name)
Registration dossier
Glutaraldehyde 50%
Registration dossier
Glutarex 28
Registration dossier
IUPAC name: 1,5-Pentanedial
Registration dossier
Pentanedial (9CI)
Registration dossier
Protectol GA 50 (trade name)
Registration dossier
Protectol GDA (trade name)
Registration dossier
Relugan 50 GT
Registration dossier
Sepacid GA 50
Registration dossier
Synonyms: glutardialdehyde, glutaric dialdehyde, glutaral
Registration dossier
Tradenames: UCARCIDE(TM) 50 Antimicrobial
Registration dossier
UCARCIDE(TM) 250 Antimicrobial
Registration dossier
107950-89-0
CAS number
Other
111-30-8
CAS number
EC Inventory, C&L Inventory, Biocidal active substances, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation Annex V, Allowed Preservatives, EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
1428979-54-7
CAS number
Other
1497435-71-8
CAS number
Other
37245-61-7
CAS number
Other
605-022-00-X
Index number
C&L Inventory
79215-57-9
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Sweetish (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
-33 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 2 studies processed
R Boiling point
101.5 - 102 °C @ 98.71 - 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.13 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 3 studies submitted
  • 3 studies processed
R Vapour pressure
13 - 3 000 Pa @ 20 - 26.3 °C [4]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
-0.36 @ 23 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 1 study processed
R Autoflammability / self-ignition
395 °C @ 100.2 - 100.6 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
No (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R kinematic viscosity (in mm²/s)
12.75 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
8.2 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation Half-life (DT50)
18 - 49 days [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
326

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0.011 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.5 µg/L (1)
Intermittent releases (freshwater) 6 µg/L (1)
Marine water 250 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 800 µg/L (1)
Sediment (freshwater) 91 µg/kg sediment dw (1)
Sediment (marine water) 9 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 210 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 800 - 39 000 µg/L [6]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
10 mg/L
LC50 for marine water fish
39 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (3.233 months) 1.6 - 3.2 mg/L [2]
LOEC (3.233 months) 5 - 10 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
EC50 (4 days) 780 µg/L [1]
EC50 (48 h) 2.1 - 29.73 mg/L [4]
LC50 (4 days) 5.5 mg/L [1]
LC50 (48 h) 3 - 5.8 mg/L [3]
NOEC (4 days) 160 µg/L [1]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 5 - 10 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 375 - 1 200 µg/L [4]
NOEC (72 h) 25 - 50 µg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (30 min) 80 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (14 days) 170 - 500 mg/kg soil dw [3]
LC50 (14 days) 150 mg/kg soil ww [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
170 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (19 days) 901 - 1 000 mg/kg soil dw [5]
EC25 (19 days) 450 - 1 000 mg/kg soil dw [7]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1.219 g/kg soil dw
Long-term EC10 / LC10 / NOEC
169 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC10 (28 days) 10.45 - 35 mg/kg soil dw [4]
EC10 (28 days) 9.2 - 15.4 mg/kg soil ww [2]
EC50 (28 days) 1.045 - 2.091 g/kg soil dw [3]
EC50 (28 days) 546 - 925 mg/kg soil ww [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (Other toxicological threshold) 210 µg/m³ repeated dose toxicity
Acute /short term: (Other toxicological threshold) 420 µg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.25 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
Hazard unknown (no further information necessary as no exposure expected)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 6
Supporting study 13
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 22 studies submitted
  • 1 study processed
P/RResults
LD50 154 - 246 mg/kg bw (rat) [3]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 21
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 28 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 280 - 390 mg/m³ air (rat) [3]
M/CInterpretations of results
Category 2 based on GHS criteria [1]

inhalation
Studies with data
Key study 1
Supporting study 25
Weight of evidence
Other 1 1
Data waiving
no waivers
dermal
  • 18 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 1
Supporting study 17
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 8 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 77 mg/kg bw
Inhalation route:
Adverse effect observed LC50 280 mg/m³
Dermal route:
No adverse effect observed Discriminating dose 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 25
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 21 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 17
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 14.95 - 46 mg/kg bw/day [6]
NOAEL (dog): 14.6 - 16.6 mg/kg bw/day [2]
NOAEL (dog): 500 ppm [1]
LOAEL (rat): 116.6 - 153.2 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 12 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 0.125 - 1 ppm [3]
NOAEC (mouse): 0.062 - 0.125 ppm [3]
LOAEC (rat): 0.25 ppm [2]
LOAEC (mouse): 0.062 - 0.125 ppm [2]

Study data: inhalation
Studies with data
Key study 4
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 150 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 15 mg/kg bw/day (subchronic, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 150 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 500 µg/m³ (chronic, mouse)
Inhalation route - local effects:
Adverse effect observed NOAEC 250 µg/m³ (chronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 43 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 39
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant