Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-545-4
CAS no.:
108-05-4
Index number:
Molecular formula:
C4H6O2
SMILES:
CC(=O)OC=C
InChI:
InChI=1S/C4H6O2/c1-3-6-4(2)5/h3H,1H2,2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
40
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP05) approved by the European Union, this substance is a highly flammable liquid and vapour, is harmful if inhaled, is suspected of causing cancer and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful to aquatic life with long lasting effects.

Breakdown of all 2027 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Carc. 2 H351 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Aquatic Chronic 3 H412
STOT RE 2 H373
STOT SE 2 H371
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 154 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, cosmetics and personal care products, air care products, fillers, putties, plasters, modelling clay and polymers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: paper used for articles with intense direct dermal (skin) contact during normal use such as printed articles (e.g. newspapers, books, magazines, printed photographs).

This substance is used in the following products: laboratory chemicals, adhesives and sealants, coating products, inks and toners and pH regulators and water treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development, health services and building & construction work.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: polymers, cosmetics and personal care products and textile treatment products and dyes.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, mixing in open batch processes, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: polymers, adhesives and sealants, coating products, inks and toners and laboratory chemicals.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Read label before use.

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; ground and bond container and receiving equipment; take actions to prevent static discharges; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; keep container tightly closed; use personal protective equipment as required.; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; use non-sparking tools; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. If exposed or concerned: get medical advice/attention. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • A.Schulman Polska Sp. z o.o, ul. Puławska 424 02-884 Warszawa Poland
  • Amcor Flexibles Winterbourne, Winterbourne Road Stoke Gifford BS34 6PT Bristol South Gloucestershire United Kingdom
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • ARKEMA PHOTOCURES, 420 rue d'Estienne d'Orves 92700 Colombes France
  • Ashland Services BV (OR2), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • AT&SERVICE SRL, Via Scassata s.c., CONDOMINIO MP-Capannone A3 Loc. Spartimento 81050 Pastorano CE Italy
  • Avery Dennison Materials Europe BV, Willem Einthovenstraat 11 2342 BH Oegstgeest Zuid-Holland Netherlands
  • AVX Limited, Prospect House 6 Archipelago Lyon Way GU16 7ER Frimley Surrey United Kingdom
  • B-Lands Consulting (811385-0), World Trade Center, 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • B.I.G. - OR641, Technische Schoolstraat 43A 2440 Geel Belgium
  • BASF Agricultural Specialities Limited, Harwood Industrial Estate, Harwood Road BN17 7AU Littlehampton, West Sussex United Kingdom
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Bemis Valkeakoski Oy, PO Box 70 Teollisuustie 1 37601 Valkeakoski Finland
  • Bison International B.V., Dr. A.F. Philipsstraat 9 4462 EW Goes Netherlands
  • Borealis AG, Wagramerstrasse 17-19 1220 Vienna Austria
  • Bostik Nederland B.V., Zeggeveld #10 RP4705 Roosendaal Netherlands
  • BSM-OR-polymers-Equistar, Delftseplein 27E 3013 AA Rotterdam Netherlands
  • C.S.B. GmbH, Düsseldorfer Str. 113 47809 Krefeld Germany
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • Celanese Production Germany GmbH & Co. KG, Am Unisys-Park 1 65843 Sulzbach Germany
  • Celanese Services Germany GmbH OR 1, Am Unisys-Park 1 D-665843 Sulzbach Germany
  • Celanese Services Germany GmbH OR 3, Am Unisys-Park 1 D-65843 Sulzbach Germany
  • Celanese Services Germany GmbH OR 4, Am Unisys-Park 1 D-65843 Sulzbach Germany
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • Chementors Oy, Smart Chemistry Park Raisionkaari 55 21200 Raisio Finland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, ROOM 002, REGUS HARCOURT CENTRE D02 HW77 DUBLIN Ardee Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Henan Botai Chemical Building Materials Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service(CIRS) Limited(Tianpu Chemicals Company Limited), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CS Regulatory Ltd 1L-22, The Old Courthouse St Peters Churchyard DE1 1NN Derby United Kingdom
  • Cyber Clean Europe GmbH, Enzianstraße 6 82319 Starnberg Germany
  • Denka Chemicals GmbH, Kaiserswerther Str. 183 D-40474 Dusseldorf Germany
  • DLP Industry B.V., Prins Mauritslaan 41-47 1171 LP Badhoevedorp Netherlands
  • DOW AGROSCIENCES B.V. (BE), Avenue des Arts 44 1040 Brussels Belgium
  • DOW AGROSCIENCES ITALIA S.R.L., Via Albani 65 20148 Milano Italy
  • DOW AGROSCIENCES LIMITED, CPC2 Capital Park, Fulbourn Cambridge CB21 5XE Cambridgeshire United Kingdom
  • DOW AGROSCIENCES S.A.S., Equinoxe 2 1bis avenue du 8 Mai 1945 78280 Guyancourt France
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR2, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-4, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-5, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW OLEFINVERBUND GMBH, Strasse B 13 D-06258 Schkopau Germany
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 173-175 D-63263 Neu-Isenburg Hesse Germany
  • DuPont Solutions (France) SAS, Equinoxe 2 1bis avenue du 8 Mai 1945 78280 Guyancour France
  • ELC Group s.r.o., Karolinská 650/1 186 00 Prague 8 Czech Republic
  • ERM_GmbH_OR13_KM, Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany
  • Euro-Trade Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa, Łokietka 155 31-263 Kraków Poland
  • EVAL Europe, Haven 1053 Nieuwe Weg 1 B2070 Zwijndrecht Antwerp Belgium
  • Everkem Srl, Via Melchiorre Gioia, 168 20125 Milano Italy
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Gantrade Europe Limited, Birch House Fairfield Avenue TW18 4AB Staines Upon Thames Middlesex United Kingdom
  • GIFI DIFFUSION, la Barbiere 47300 VILLENEUVE SUR LOT France
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Henkel AG & Co. KGaA - Only Representative HCorpUSA, Henkelstrasse 67 40191 Duesseldorf Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hoeganaes Corporation Europe S.A., 33 Urziceni Street 120226 Buzau Buzau Romania
  • Honeywell Belgium NV OR-1000, Gaston Geenslaan 14 - 2nd Floor Arenberg Wetenschapspark B-3001 Heverlee Belgium
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • Ineos Manufacturing (Hull) Ltd (VAM) - MI, Saltend Hedon HU12 8DS Hull United Kingdom
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Intertek Deutschland GmbH, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 1, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 16, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH CLIL, Stangenstr.1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • Intertek Deutschland GmbH_NAHL, Stangenstr.1 70771 Leinfelden-Echterdingen Germany
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Intertek Semko AB 10, Torshamnsgatan 43 SE-164 22 Kista Sweden
  • Italmatch Chemicals Spa, Via Magazzini del Cotone 17 – modulo 4 16128 Genova Italy
  • Jowat SE, Ernst-Hilker-Str. 10 - 14 32758 Detmold NRW Germany
  • Kaufland Dienstleistung GmbH & Co. KG, Rötelstraße 35 74172 Neckarsulm Germany
  • KCC Europe GmbH, Hansaring 61 50670 Köln Germany
  • KH Chemicals B.V., Scheepmakerij 260 3331 MB Zwijndrecht Netherlands
  • KiK Textilien und Non-Food GmbH, Siemensstrasse 21 59199 Boenen Germany
  • KIST Europe Forschungsgesellschaft mbH, Universitaet des Saarlandes Campus E 71 D-66123 Saarbruecken Germany
  • Koopman International B.V., Distelweg 88 1031 HH Amsterdam Netherlands
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH, Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Kuraray Europe GmbH (OR2), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • LCNBV-OR-LaPorte, Weena 737 3013 AM Rotterdam Netherlands
  • Lifosa-2, Juodkiskio 50 LT-57502 Kedainiai Lithuania
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • LuerChem, NOWOGRODZKA 50 LOK 521 02-695 Warsaw Poland
  • LUKOIL Neftohim Burgas AD (LNH Moscow Stav), Western Industrial Zone 8104 Bourgas Bulgaria
  • Lyondell Chemie Nederland B.V., Deltseplein 27E 3013 AA Rotterdam Netherlands
  • Mascot Europe BV, Westerblokker 32B 1695 AH BLOKKER Netherlands
  • MEMENTO s.r.l., Via Adriano Olivetti 24 00131 Rome Italy
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • Mitsubishi Chemical Europe GmbH 01, Willstätterstraße 30 40549 Düsseldorf Germany
  • Mitsubishi Chemical Europe GmbH 02, Willstätterstraße 30 40549 Düsseldorf Germany
  • MÄC GEIZ Handelsgesellschaft mbH, Zörbiger Straße 6b 06188 Landsberg Germany
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • Normachem Srl, Via Roma, 14 35014 Fontaniva PD Italy
  • Nouryon Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • OMNOVA Solutions SAS, 14 avenue des tropiques ZA de Courtaboeuf 2, Villejust 91955 Courtaboeuf Cedex France
  • OSTCHEM Germany GmbH Sev, Erdmannstr. 10 22765 Hamburg Germany
  • PARAMELT B.V., Costerstr. 18 1704 RJ Heerhugowaard Netherlands
  • Performance Materials Ibérica, S.L.U., Jose Abascal 56 28003 Madrid Spain
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PRYSE, S.A., Lisboa, 6. Pol. Ind. Cova Solera 08191 Rubi Barcelona Spain
  • Pulcra Chemicals GmbH, Isardamm 79-83 82538 Geretsried Germany
  • RAYHER HOBBY GmbH, Fockestr.15 88471 Laupheim Germany
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Saati S.p.A., via Milano 14 22070 Appiano Gentile Como Italy
  • SAFC Biosciences Limited, Smeaton Road, West Potway SP10 3LF Andover United Kingdom
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Sekisui Specialty Chemicals Europe S.L., Carretera Nacional 340 Km. 1157 43110 Tarragona Spain
  • SHOWA DENKO EUROPE GmbH, KONRAD-ZUSE-PLATZ 3 81829 München Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sinopec Europa GmbH, Messe Turm Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • Sinopec Europa GmbH, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • Solutia Europe BV, Ottergemsesteenweg Zuid 707 9000 Gent Belgium
  • Specialized Technology Resources España, Parque Tecnológico de Asturias P.36 33428 Llanera Spain
  • Stafford-Miller (Ireland) Limited, Clocherane Youghal Road _ Dungarvan Waterford Ireland
  • Synthomer (UK) Limited, Central Road Templefields CM20 2BH Harlow Essex United Kingdom
  • Synthomer Trading Limited, 45 Pall Mall SW1Y 5JG London United Kingdom
  • TEDi GmbH & Co. KG, Brackeler Hellweg 301-305 44309 Dortmund NRW Germany
  • Teknor Apex BV, Mijnweg 1 Mijnweg 1, (P.O.Box 601, 6160 AP) 6167AC Geleen Please select Netherlands
  • TIGI Haircare GmbH, Hertzstraße 6 71083 Herrenberg Germany
  • UHU GmbH & Co. KG, Herrmannstraße 7 77815 Bühl (Baden) Germany
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • Varistone BV, De Hogenkamp 22 7071 EC Ulft Netherlands
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • Wacker Chemie AG (OR_WCC), Johannes-Hess-Strasse 24 84489 Burghausen Germany
  • WOOLWORTH GmbH, Formerstr.6 59425 Unna NRW Germany
  • Zebra A/S, Strandgade 71-73 1401 Copenhagen Denmark
  • [Confidential], [Confidential]
  • BTC Europe GmbH, Rheinpromenade 1 40789 Monheim Germany
  • Celanese Chemicals Ibérica, S.L., Carretera Nacional 340, Km. 1155 Polígono Industrial TAQSA E-43.206 Reus (Tarragona) Spain
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Henkel AG & Co. KGaA, Henkelstrasse 67 40191 Duesseldorf North-Rhine Westfalia Germany
  • Henkel Belgium Operations N.V., Havenlaan 16 1080 Brussels Belgium
  • Henkel Italia Operations S.r.L., Via Amoretti 78 20157 Mailand Italy
  • Henkel Polska Operations SP.z.o.o., Domaniewska 41 02-672 Warszawa Poland
  • Specialty Electronic Materials Netherlands BV OR-4, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • TJ Morris Ltd, Portal Way L11 0JA Liverpool Merseyside United Kingdom

Substance names and other identifiers

acetic acid, vinyl ester
FCM and Articles Regulation, Annex I - Authorised Substances
Vinyl acetate
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, Occupational Exposure Limits - 3rd list - Indicative OELVs, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
VINYL ACETATE, STABILIZED
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
acetato de vinilo (es)
C&L Inventory
acetato di vinile (it)
C&L Inventory
acétate de vinyle (fr)
C&L Inventory
ester winylowy kwasu octowego (pl)
C&L Inventory
octan winylu (pl)
C&L Inventory
vinil acetat (ro)
C&L Inventory
vinil-acetat (hr)
C&L Inventory
vinil-acetát (hu)
C&L Inventory
vinilacetatas (lt)
C&L Inventory
vinilacetāts (lv)
C&L Inventory
vinile acetato (it)
C&L Inventory
vinyl-acetát (cs)
C&L Inventory
vinylacetaat (nl)
C&L Inventory
vinylacetat (da)
C&L Inventory
Vinyyliasetaatti (fi)
C&L Inventory
Vinüülatsetaat (et)
C&L Inventory
οξικός βινυλεστέρας (el)
C&L Inventory
винил ацетат (bg)
C&L Inventory
Acetic acid ethenyl ester
Other
1-Acetoxyethylene
Registration dossier
1-Acétoxyéthylène Ethanoate d'éthényle
C&L Inventory
acetic acid vinyl ester
C&L Inventory
Acetic acid, ethenyl ester
C&L Inventory
Acetoxyethylene
Registration dossier
Ethenyl acetate
C&L Inventory, Registration dossier, Other
Ethenyl ethanoate
C&L Inventory, Registration dossier
inq_vinyl acetate
Registration dossier
Reaction mass of ethylene and vinyl acetate
C&L Inventory
VA
Registration dossier
Vinyl acetate as a polymer constituent in imported polymers
Registration dossier
VINYL ACETATE MONOMER
C&L Inventory, Registration dossier
Vinyl Acetate Monomer (stabilized with HQ)
C&L Inventory
Vinyl acetate rectificate
Registration dossier
VINYL ACETE
C&L Inventory
AC 400
Registration dossier
ACETIC ACID, ETHYLENE ETHER
Registration dossier
acetoxy ethylene
Registration dossier
ETHANOIC ACID, ETHENYL ESTER
Registration dossier
Ethenyl ester
Registration dossier
VAM
Registration dossier
Vinyl Acetate Monomer (VAM)
Registration dossier
Vinyl acetate; Ethenyl acetate
Registration dossier
VINYL ETHANOATE
Registration dossier
108-05-4
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, Occupational Exposure Limits - 3rd list - Indicative OELVs, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
172702-77-1
CAS number
Other
220713-36-0
CAS number
Other
607-023-00-0
Index number
C&L Inventory
61891-42-7
CAS number
Other
82041-23-4
CAS number
Other
85306-26-9
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Not specified (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-93.2 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-93.45 °C

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
72.7 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
72.7 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Density
0.93 g/cm³ @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
932

Vapour pressure

Study results
  • 2 studies submitted
  • 1 study processed
R Vapour pressure
11.3 kPa @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
11.3 kPa @ 20 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
0.73 @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.73 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
20 g/L @ 20 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
20 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
-8 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-8.15 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
402 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
402.05 °C

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Extremely flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.42 - 0.43 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.42 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
14.6 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
14.6 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
24.21

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
51.6 Pa m³/mol @ 20 °C and 101.33 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
56.1 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 16 µg/L (1)
Intermittent releases (freshwater) 126 µg/L (1)
Marine water 1.6 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 6 mg/L (1)
Sediment (freshwater) 67 µg/kg sediment dw (1)
Sediment (marine water) 6.7 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 3.5 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (34 days) 551 µg/L [1]
LOEC (34 days) 930 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
160 µg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 12.6 mg/L [1]
EC50 (24 h) 24 mg/L [1]
NOEC (48 h) 4.77 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 7.48 - 12.7 mg/L [3]
NOEC (72 h) 1.58 - 5.96 mg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
12.7 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
6 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 17.6 mg/m³ carcinogenicity
Acute /short term: (DNEL) 35.2 mg/m³ irritation (respiratory tract)
Local Effects
Long-term: (DNEL) 17.6 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 35.2 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 420 µg/kg bw/day carcinogenicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 6 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Absorption values
Dermal: 90 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 3.73 - 3.76 mL/kg bw (rat) [2]
M/CInterpretations of results
Sligthly toxic [1]

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 4 490 ppm (rat) [1]
M/CInterpretations of results
Moderately toxic [1]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 3 1
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 8 mL/kg bw (rabbit) [1]
M/CInterpretations of results
Sligthly toxic [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 684 - 810 mg/kg bw/day [2]
NOAEL (rat): 5 000 ppm [1]
NOAEL (mouse): 281 - 285 mg/kg bw/day [2]
NOAEL (mouse): 5 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 7 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 50 - 200 ppm [2]
NOAEC (mouse): 50 ppm [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LOAEL 31 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant