Registration Dossier
Registration Dossier
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EC number: 615-275-8 | CAS number: 71301-98-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Principles of method if other than guideline:
- no guideline specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl 2-(4-hydroxyphenoxy)propionate
- EC Number:
- 265-704-4
- EC Name:
- Ethyl 2-(4-hydroxyphenoxy)propionate
- Cas Number:
- 65343-67-1
- IUPAC Name:
- ethyl 2-(4-hydroxyphenoxy)propanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Polyethylenglycol 400
- Controls:
- no
- Duration of treatment / exposure:
- 24h
- Observation period:
- 72h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.056
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.72
- Max. score:
- 2
- Reversibility:
- no data
- Remarks on result:
- other: scarified skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.22
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other: scarified skin
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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