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EC number: 700-202-5
CAS number: 765-63-9
An acute toxicity rat study on 2,2,3,3-tetrafluorooxetane (TFO) was
carried out by Huntingdon Life Sciences, Huntingdon Research Centre, UK
on behalf of the Shin-Etsu Chemical, Japan.
The acute toxic class method is a stepwise procedure that uses three
animals of a single sex per step. Depending on the mortality and/or the
moribund status of the animals, on average two to four steps may be
necessary to allow a judgement on the acute toxicity of the test substance.
The study was conducted in accordance with Good Laboratory Practice
Two groups of three fasted female rats received a single oral gavage
dose of the test substance, formulated in corn oil, at a dose level of
300 mg/kg bodyweight. As results at this dose level indicated the acute
(median) lethal oral dose of the test substance to be greater than 300
mg/kg bodyweight, in compliance with the study guidelines a further
group of three fasted females were similarly dosed at 2000 mg/kg
bodyweight to complete the study.
The acute median lethal oral dose (LD50) to rats of TFO was demonstrated
to be between 300 and 2000 mg/kg bodyweight.
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