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EC number: 850-779-3
CAS number: 115888-13-6
The eye hazard potential of N,N´-Di-L-Alanyl-L-Cystine /
(L-Ala-L-Cys)2 was evaluated in a Bovine Corneal Opacity and
Permeability Assay (BCOP) according to OECD TG 437. The test item did
not induce ocular irritation through both endpoints, resulting in a mean
in vitro irritancy score of 0.2 after 4 hours of treatment. In
conclusion, since N,N´-Di-L-Alanyl-L-Cystine / (L-Ala-L-Cys)2 induced an
IVIS ≤ 3, no classification is required for eye irritation or serious
The skin irritation and corrosion potential of
N,N´-Di-L-Alanyl-L-Cystine / (L-Ala-L-Cys)2 was evaluated in two studies
using human three dimensional epidermal models according to OECD TG 431
and OECD TG 439. The test item did not induce skin irritation or
corrosion. In conclusion no classification is required for skin
irritation or skin corrosion.
N,N´-Di-L-Alanyl-L-Cystine / (L-Ala-L-Cys)2 induced an IVIS ≤ 3.
Therefore, no classification is required for eye irritation or serious
N,N´-Di-L-Alanyl-L-Cystine / (L-Ala-L-Cys)2 did not induce skin
irritation or skin corrosion in studies using EpiDerm as skin model.
Therefore, no classification is required for skin irritation or skin
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