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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
Version / remarks:
1996
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
1.5 µm
St. dev.:
0.02
Key result
Percentile:
D50
Mean:
5.6 µm
St. dev.:
0.16
Percentile:
D90
Mean:
14.5 µm
St. dev.:
0.54
Conclusions:
According to ISO 13320 (2009) and OECD Test Guideline 110 (1981) the median particle size D50 of the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 was determined by laser diffraction measurement to be:
D50 = 5.6 µm

Description of key information

median particle size D50 = 5.6 µm (OECD 110, GLP)

Additional information

According to ISO 13320 (2009) and OECD Test Guideline 110 (1981) the median particle size D50 of the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 was determined by laser diffraction measurement to be:

D50 = 5.6 µm

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