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Flammability

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Endpoint:
flammable solids
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: VDI Guideline 2263, Part 1
Version / remarks:
1990
Deviations:
no
Qualifier:
according to guideline
Guideline:
UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)
Version / remarks:
2019
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Key result
Test procedure:
burning rate test: preliminary screening test
Remarks on result:
substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period
Interpretation of results:
not classified based on GHS criteria
Conclusions:
According to UN Test N.1 the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 could not be ignited applying a flame as ignition source for at least 2 minutes.
The test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as readily combustible solid in Class 4, Division 4.1 – Flammable solids according to the UN Transport Regulation.
GHS (CLP Regulation (EC) No 1272/2008: Annex I: 2.7): The test item does not have to be classified as flammable solid according to GHS / CLP Regulation (EC) No 1272/2008: Annex I: 2.7.
Endpoint:
self-heating substances / mixtures
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: VDI Guideline 2263, Part 1
Version / remarks:
1990
Deviations:
no
Qualifier:
according to guideline
Guideline:
UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
Version / remarks:
2019
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Key result
Test procedure:
other: Grewer Oven
Max. temp. reached:
545
Result:
negative outcome (no effect observed)
Interpretation of results:
not classified based on GHS criteria
Conclusions:
The pure test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 indicated self-ignition at atmospheric pressure starting at a temperature of 230 °C. Due to the high onset temperature in the Grewer Oven, it can be assumed that the UN Test N.4 using the 100 mm cube sample at 140 °C is negative.
On the basis of the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.
GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item does not have to be classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11.

Description of key information

not flammable (UN Test N.1, GLP)

not self-heating (Grewer oven, GLP)

Key value for chemical safety assessment

Flammability:
not classified

Additional information

According to UN Test N.1 the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 could not be ignited applying a flame as ignition source for at least 2 minutes.

The pure test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 indicated self-ignition at atmospheric pressure starting at a temperature of 230 °C. Due to the high onset temperature in the Grewer Oven, it can be assumed that the UN Test N.4 using the 100 mm cube sample at 140 °C is negative.

Justification for classification or non-classification

According to UN Test N.1 the substance is classified as follows:

UN Transport Regulation: The test item does not have to be classified as readily combustible solid in Class 4, Division 4.1 – Flammable solids according to the UN Transport Regulation.

GHS (CLP Regulation (EC) No 1272/2008: Annex I: 2.7): The test item does not have to be classified as flammable solid according to GHS / CLP Regulation (EC) No 1272/2008: Annex I: 2.7.

On the basis of the results of the tests on the self-ignition in the Grewer Oven the substance is classified as follows:

UN Transport Regulation: The test item does not have to be classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.

GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item does not have to be classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11.