3,3'-methylenebis[5-methyloxazolidine]

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

other information

Study period:

Experimental start and termination: 2001-05-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Guideline study (OECD 116) in compliance with GLP.

Qualifier:

according to guideline

Guideline:

OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)

GLP compliance:

yes (incl. QA statement)

Medium:

standard fat

Solubility:

> 3 560 g/kg solvent

Temp.:

37 °C

Remarks on result:

other: Substance highly soluble in standard fat. No saturation up to 7.12 g / 2 g standard fat.

Conclusions:

The solubility in standard fat was analysed according to guideline OECD 116. The substance was considered highly soluble in standard fat, as the solubility was >3560 mg/kg at 37 °C.

Description of key information

The solubility of 3,3’-Methylen-bis-[5-methyl-oxazolidine] in standard fat was analysed according to guideline OECD 116. The substance was considered highly soluble in standard fat, as the solubility was >3560 mg/kg at 37 °C. Solubility in n-heptane was determined as 500 – 1000 mg/L (20.5 ± 0.5°C) by Hach Method 8195 (based on USEPA 180.1). Solubility in in other organic solvents was analysed by visual inspection for turbidity or phase separation at 21-23 °C. 3,3’-Methylen-bis-[5-methyl-oxazolidine] was completely miscible with DMSO, Ethanol, n-octanol and acetone as well as partially soluble in toluene and cyclohexane.