Registration Dossier
Registration Dossier
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EC number: 689-732-5 | CAS number: 956317-36-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test article was evaluated at a concentration of 25% in DMSO, with DMSO as the vehicle control and 25% HCA as the positive control.
All animals survived the in-life phase of the study and were observed to be normal. Ear thickness measurements and clinical observations indicated that treatment with the test article did not result in dermal irritation.
Migrated from Short description of key information:
In a LLNA study in mice, topical application of the test article at 25% in DMSO resulted in an SI value of 1.6. Therefore, the test article was considered not to be a skin sensitizer.
Justification for classification or non-classification
The substance does not meet classification criteria under EU Directive 67/548/EEC for sensitisation.
The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for skin sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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