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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
GLP compliance:
yes (incl. QA statement)
Type of study:
other: LuSens cell line

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4,5-tetramethyl-1H-imidazole
EC Number:
217-100-7
EC Name:
1,2,4,5-tetramethyl-1H-imidazole
Cas Number:
1739-83-9
Molecular formula:
C7H12N2
IUPAC Name:
tetramethyl-1H-imidazole

Results and discussion

In vitro / in chemico

Results
Run / experiment:
other: LuSens test
Parameter:
other: The viability values
Value:
88

Any other information on results incl. tables

Under the experimental conditions of this study, the test item, 1,2,4,5-Tetramethylimidazole, was positive in the LuSens assay and is therefore considered to have the potential to activate the Nrf2 transcription factor.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
positive