Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4,5-tetramethyl-1H-imidazole
EC Number:
217-100-7
EC Name:
1,2,4,5-tetramethyl-1H-imidazole
Cas Number:
1739-83-9
Molecular formula:
C7H12N2
IUPAC Name:
tetramethyl-1H-imidazole

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw

Any other information on results incl. tables

Under the test conditions, the test item1,2,4,5-tetramethyl-1H-imidazole,when administered by oral route in female rats, cause deaths, for every step taken at the dose levels of2000mg.Kg-1ofbody weight.In clinical examinations, the tested animals showsystemic signs of toxicity. In macroscopic evaluations noalterations were observed during the necropsies.Based on the flow chart with the starting dose of 2000 mg.Kg-1ofbody weight, the test item was classified as category 4 (>300-2000), according to the GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures).The oral LD50value of test item1,2,4,5-tetramethyl-1H-imidazole,for female rats, was estimated in500 mg.Kg-1of body weight.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
>2000 mg.Kg-1