Registration Dossier
Registration Dossier
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EC number: 437-760-1 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 11 to 15, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 30th March 1989
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- Directive 92/69/EEC
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on September 22, 1999 / signed on January 18, 2000
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.94
- Temp.:
- 21 °C
- pH:
- ca. 0 - ca. 14
- Conclusions:
- The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
- Executive summary:
The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.
The system was adequately calibrated with 6 reference substances, and the test substance was interpolated from the regression.
Partition coefficient (log Kow) = 2.94 at 21°C.
Reference
| Substance | retention time (tr) | k' | log Pow |
| Formamide (dead time) | 1.54 min | --- | --- |
| Methyl benzoate | 3.13 min | 1.04 | 2.1 |
| Toluene | 4.77 min | 2.11 | 2.7 |
| Bromobenzene | 5.30 min | 2.45 | 3.0 |
| Naphthalene | 6.74 min | 3.39 | 3.6 |
| Benzyl benzoate | 8.40 min | 4.47 | 4.0 |
| Phenanthrene | 16.5 min | 9.76 | 4.5 |
| ST 16 C 99 | 4.90 min | 2.19 | 2.94 ± 0.01 |
Log Pow = 2.64 * log k' + 2.04
r2 = 0.96
Description of key information
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.94
- at the temperature of:
- 21 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
